Incomplete Regulation of NF-kB by IkBa during Respiratory Syncytial Virus Infection in A549 Cells

Inducible translational regulation of the NF-IL6 transcription factor by respiratory syncytial virus infection in pulmonary epithelial cells.

Respiratory syncytial virus (RSV), the most common etiologic agent of epidemic pediatric respiratory disease, infects and replicates in the human airway epithelium, resulting in the induction of cellular gene products essential for immune and inflammatory responses. We describe the effect of RSV infection on nuclear factor-IL6 (NF-IL6) expression, a human basic domain-leucine zipper-containing ...

Essential roles of NF-kappaB and C/EBP in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelial cell cultures.

To determine the molecular mechanism(s) of respiratory syncytial virus (RSV)-induced intercellular adhesion molecule-1 (ICAM-1) upregulation in respiratory epithelial cells (REC; A549 cell cultures), we investigated the roles of the transcription factors NF-kappaB and C/EBP. Increases in ICAM-1 message required de novo mRNA synthesis. ICAM-1 promoter constructs (luciferase reporter gene) transf...

Inhibition of viral replication reverses respiratory syncytial virus-induced NF-kappaB activation and interleukin-8 gene expression in A549 cells.

Previous studies have demonstrated that respiratory syncytial virus (RSV) infection of airway epithelial cells results in the expression of a number of cytokines, such as interleukin-8 (IL-8), that are transcriptionally regulated by nuclear factor kappaB (NF-kappaB). In the studies reported here, we demonstrate that treatment of RSV-infected A549 cells with 100 microg of ribavirin (a viral repl...

Inhibition of Viral Replication Reverses Respiratory Syncytial Virus-Induced NF-kB Activation and Interleukin-8 Gene Expression in A549 Cells

Respiratory Syncytial Virus Infection in Patients Referred to Kasra Hospital Laboratory during 2016-2019: A Continuous Study:

Abstract One of the main cause of severe respiratory infection in infants and young children is respiratory syncytial virus (RSV). The disease can also occur in adults and elderly individuals and clinically not to be differentiated from other viral respiratory infection. The disease causes bronchiolitis, and sometimes pneumonia in new born and young children which requires hospital care. To di...